They are without a win in 4 consecutive matches. On away they are without stability at the back. In 6 away matches conceded 10 goals. I see troubles again because two top defenders Drameh & McLoughlin are on the bench. I can't imagine clean sheet for guests without them in starting lineup.
Oxford is solid at home - went unbeaten in 6 of the 7 home league matches and conceded only 5 goals in the process.
I believe defensive formation and home advantage will make difference here.