PSV have won by three or more goals in four of their last five starts
The Dutch side have won 15-0 across their last three home matches
Shakhtar have failed to score in three of their four games in Europe this term
PSV to cruise to victory
PSV boosted their hopes of progressing in the Champions League with a comfortable 4-0 win over Girona last time out. The Eredivisie pacesetters are heavy favourites to follow that up with a victory on Wednesday, given that Shakhtar have scored in just one of their four matches so far.
The Dutch side have won by three clear goals in four of their last five games and they head into this having won 15-0 on aggregate across their previous three home matches.
PSV have opened the scoring in all but one of their home matches this season and they can strike early again to take control of this one. The hosts have led at the break in their last three European outings – against Sporting, PSG and Girona. This looks like a more straightforward fixture, so back them to clear a -1 handicap in a 3-0 victory.