Plymouth have scored just seven goals in 19 competitive away games.
Manchester City have won to nil in two of their last four games.
Pilgrims’ FA Cup run to end in Manchester
After a shock early exit from the Champions League and a defeat to Premier League leaders Liverpool, the FA Cup is now Manchester City’s only realistic hope of silverware this season and they should be able to cruise into the quarter-finals with a win over Plymouth on Saturday.
The Pilgrims stunned Liverpool with a fourth-round win at Home Park last month, but they have only won one of their 19 competitive away games this season and have scored a meagre seven goals in the process.
That single victory did come against Premier League opposition in this competition, but Manchester City have already seen off two lower-league clubs in the FA Cup and two of their last four games have ended in them keeping a clean sheet in victory.
Backing the home side to win to nil appeals, and with Plymouth conceding exactly twice in two of their last three away games, a repeat of their 2-0 loss at Blackburn recently appeals in the correct score market.
Predictions:Manchester City To Win To Nil Manchester City 2-0